Banca de DEFESA: JHENIFFER DA SILVA SOUSA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE: JHENIFFER DA SILVA SOUSA
DATA: 07/04/2026
HORA: 14:00
LOCAL: DEPARTAMENTO DE BIOFISICA
TÍTULO: Stable systemic iron homeostasis despite redox and inflammatory remodeling in women with breast cancer
PALAVRAS-CHAVES: Breast cancer; Iron metabolism; Oxidative stress; Inflammation.
PÁGINAS: 128
GRANDE ÁREA: Ciências Agrárias
ÁREA: Ciência e Tecnologia de Alimentos
RESUMO:

Breast cancer is associated with systemic metabolic and inflammatory alterations that may
influence tumor progression and host physiology. However, the relationship between iron
metabolism, redox balance, inflammation, and structural cellular markers in patients remains
incompletely understood. Here, we investigated the interaction between systemic iron
parameters, oxidative stress markers, inflammation, body composition, and dietary intake in
women with breast cancer compared with healthy controls. In this cross-sectional study including
40 women (23 with breast cancer and 17 controls), patients with cancer exhibited a significantly
lower phase angle, higher concentrations of high-sensitivity C-reactive protein, and reduced
levels of nitrite and myeloperoxidase activity. Circulating markers of iron metabolism did not
differ significantly between groups. Energy and macronutrient intake were similar after dietary
calibration, although dietary iron intake was lower in the cancer group. Correlation analyses
revealed positive associations between ferritin and superoxide dismutase activity in patients and
between ferritin and ceruloplasmin in controls. These findings suggest that systemic
inflammatory and redox alterations occur in breast cancer despite apparently stable circulating
iron levels, highlighting a potential role for iron–redox interactions in the metabolic remodeling
associated with the disease.

MEMBROS DA BANCA:
Presidente - 2950101 - FRANCISCO LEONARDO TORRES LEAL
Externo ao Programa - 055.***.***-24 - IRISLENE COSTA PEREIRA - UFPI
Externo ao Programa - 1255891 - JULIANA SOARES SEVERO
Externo ao Programa - 3261030 - KYRIA JAYANNE CLÍMACO CRUZ
Externo ao Programa - 1118434 - STÉFANY RODRIGUES DE SOUSA MELO