Banca de DEFESA: RODRIGO SOARES PEREIRA LIMA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE: RODRIGO SOARES PEREIRA LIMA
DATA: 24/04/2026
HORA: 14:00
LOCAL: DEPARTAMENTO DE BIOFISICA
TÍTULO: Systemic Metabolic Phenotype Characterized With Visceral Adiposity, Lipid Contribution and Redox Modulation in Women With Breast Cancer
PALAVRAS-CHAVES: Adiposity; Dietary patterns; Ultra-processed foods; Breast cancer; Oxidative stress
PÁGINAS: 119
GRANDE ÁREA: Ciências Agrárias
ÁREA: Ciência e Tecnologia de Alimentos
RESUMO:

Breast cancer has increasingly been recognized as a condition associated with systemic metabolic alterations involving body composition, lipid metabolism, and oxidative balance. This crosssectional study investigated the integrated relationship between body composition, dietary intake including ultra-processed foods, metabolic profile, and oxidative stress markers in women with breast cancer compared with controls. Thirty-seven women were evaluated (20 with breast cancer and 17 controls). Anthropometric parameters and body composition were determined by bioelectrical impedance analysis. Dietary intake was estimated using a Food Frequency Questionnaire calibrated by 24-hour dietary recall, allowing the estimation of macronutrient intake, classification of foods according to the degree of processing, and quantification of the contribution of ultra-processed foods to the diet. Dietary patterns were derived using Principal Component Analysis. Glycemic and lipid profiles were determined by enzymatic-colorimetric methods, with calculation of the triglyceride–glucose (TyG) index, and oxidative stress markers were measured by spectrophotometry. Women with breast cancer presented higher visceral adiposity and lower phase angle, as well as lower concentrations of total cholesterol and HDL-c. Differences were also observed in nitrite and myeloperoxidase levels. The proportion of dietary lipids was higher in the breast cancer group, while the percentage of ultra-processed foods was similar between groups. Principal component analysis identified distinct structural organization of dietary patterns between groups, reflecting different associations among food groups. Discriminant analysis demonstrated clear metabolic separation between the evaluated groups. Overall, the findings indicate that women with breast cancer exhibit a distinct systemic metabolic phenotype characterized by visceral adiposity redistribution, selective modulation of lipid metabolism, and alterations in redox balance, even in the absence of differences in ultra-processed food consumption. These results highlight the importance of integrated nutritional and metabolic assessment to better understand the interaction between diet, systemic metabolism, and breast cancer.

MEMBROS DA BANCA:
Externo ao Programa - 3265522 - ANA RAQUEL SOARES DE OLIVEIRA
Presidente - 2950101 - FRANCISCO LEONARDO TORRES LEAL
Externo ao Programa - 055.***.***-24 - IRISLENE COSTA PEREIRA - UFPI
Interno - 1642393 - KAROLINE DE MACEDO GONCALVES FROTA